Whole Profile Fucoidan
Category: Healthcare–Health Food
Exhibitor: SIMPSON BIOTECH CO., LTD.
Booth No: i216
Characteristic
Whole Profile Fucoidan is a multi-functional skin protector
Skin-protecting and moisturizing
Prevents skin photo aging
Inhibition of melanin accumulation
Potential combination with other skin lightening ingredients
Stimulation of skin regeneration
Simpson Biotech’s Whole Profile Fucoidan (WPF) (100~2000 kDa, 10~100 kDa, ~500 Da) can function from epidermis to dermis.
The large MW portion of WPF has compatible efficacy of skin-protecting and moisturizing activity with normal fucoidan. Mid-size portion has better efficacy to prevent skin photo aging than normal fucoidan because it has more available function groups in a single molecule. The small size portion of WPF can penetrate into dermis of skin and function as a melanin inhibitor (skin lightening) or fibroblast migration stimulator (anti-scar or skin regeneration).
Using α-MSH stimulated B16F10 cell model, WPF was proven that have inhibitory effect on melanin accumulation without any cytotoxicity at 200 ppm.(Fig.1) We have also proven that WPF has a synergistic effect on melanin inhibition with Hepasim®. WPF can efficiently inhibit cellular tyrosinase activity at 125-62.5 ppm. (Fig.2) This result illustrates the working mechanism of WPF and it is a good example of Hepasim® combination with other natural skin lightening ingredient.
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